Publications

Selected publications, patents, and related work spanning medical imaging, acoustics, molecular imaging, and clinical translation.

Selected work is highlighted first. The remaining bibliography is organized by publication type and shown in reverse chronological order.

Selected Publications

  1. Cho, J. H., Bull, C. M., Thornton, M., Gao, J., Rubin, J. M., & Steinberg, I. (2026). Thermoacoustic Ultrasound Assessment of Liver Steatosis—A Novel Approach for MASLD Diagnosis. Diagnostics, 16(5), 804. https://doi.org/10.3390/diagnostics16050804
  2. Steinberg, I., Kim, J., Schneider, M. K., Hyun, D., Zlitni, A., Hopper, S. M., Klap, T., Sonn, G. A., Dahl, J. J., Kim, C., & others. (2021). Superiorized photo-acoustic non-negative reconstruction (SPANNER) for clinical photoacoustic imaging. IEEE Transactions on Medical Imaging, 40(7), 1888–1897.
  3. Zlitni, A., Gowrishankar, G., Steinberg, I., Haywood, T., & Gambhir, S. S. (2020). Maltotriose-based probes for fluorescence and photoacoustic imaging of bacterial infections. Nature Communications, 11(1), 1250. https://doi.org/10.1038/s41467-020-14985-8
  4. Kothapalli, S.-R., Sonn, G. A., Choe, J. W., Nikoozadeh, A., Bhuyan, A., Park, K. K., Cristman, P., Fan, R., Moini, A., Lee, B. C., & others. (2019). Simultaneous transrectal ultrasound and photoacoustic human prostate imaging. Science Translational Medicine, 11(507), eaav2169.
  5. Steinberg, I., Huland, D. M., Vermesh, O., Frostig, H. E., Tummers, W. S., & Gambhir, S. S. (2019). Photoacoustic clinical imaging. Photoacoustics, 14, 77–98. https://doi.org/10.1016/j.pacs.2019.05.001
  6. Steinberg, I., Shiloh, L., Gannot, I., & Eyal, A. (2018). First-in-human study of bone pathologies using low-cost and compact dual-wavelength photoacoustic system. IEEE Journal of Selected Topics in Quantum Electronics, 25(1), 1–8.
  7. Steinberg, I., Ben-David, M., & Gannot, I. (2012). A new method for tumor detection using induced acoustic waves from tagged magnetic nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine, 8(5), 569–579. https://doi.org/10.1016/j.nano.2011.09.011

Peer-Reviewed Journal Articles

  1. Zlitni, A., Yang, S., Achterberg, F. B., Gowrishankar, G., Steinberg, I., Azevedo, C., Gambhir, S. S., & Valdez, T. A. (2024). Bridging the translation of ICG-1-maltotriose: A multimodal sensor for monitoring and detecting bacterial infections. ACS Sensors, 9(6), 2806–2814.
  2. Kim, J., Park, B., Ha, J., Steinberg, I., Hooper, S. M., Jeong, C., Park, E.-Y., Choi, W., Liang, T., Bae, J. S., & others. (2021). Multiparametric photoacoustic analysis of human thyroid cancers in vivo. Cancer Research, 81(18), 4849–4860.
  3. Yu, J. H., Steinberg, I., Davis, R. M., Malkovskiy, A. V., Zlitni, A., Radzyminski, R. K., Jung, K. O., Chung, D. T., Curet, L. D., D’Souza, A. L., & others. (2021). Noninvasive and highly multiplexed five-color tumor imaging of multicore near-infrared resonant surface-enhanced Raman nanoparticles in vivo. ACS Nano, 15(12), 19956–19969.
  4. Ilovitsh, T., Feng, Y., Foiret, J., Kheirolomoom, A., Zhang, H., Ingham, E. S., Ilovitsh, A., Tumbale, S. K., Fite, B. Z., Wu, B., & others. (2020). Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites. Proceedings of the National Academy of Sciences, 117(23), 12674–12685.
  5. Alam, I. S., Steinberg, I., Vermesh, O., van den Berg, N. S., Rosenthal, E. L., van Dam, G. M., Ntziachristos, V., Gambhir, S. S., Hernot, S., & Rogalla, S. (2018). Emerging intraoperative imaging modalities to improve surgical precision. Molecular Imaging and Biology, 20(5), 705–715.
  6. Steinberg, I., Tamir, G., & Gannot, I. (2018). A reconstruction method for the estimation of temperatures of multiple sources applied for nanoparticle-mediated hyperthermia. Molecules, 23(3), 670.
  7. Tummers, W. S., Miller, S. E., Teraphongphom, N. T., Gomez, A., Steinberg, I., Huland, D. M., Hong, S., Kothapalli, S.-R., Hasan, A., Ertsey, R., & others. (2018). Intraoperative pancreatic cancer detection using tumor-specific multimodality molecular imaging. Annals of Surgical Oncology, 25(7), 1880–1888.
  8. Herzog, A., Steinberg, I., & Ishaaya, A. A. (2017). Shaping photomechanical effects in tissue ablation using 355 nm laser pulses. Journal of Biophotonics, 10(10), 1262–1270.
  9. Steinberg, I., Turko, N., Levi, O., Gannot, I., & Eyal, A. (2016). Quantitative study of optical and mechanical bone status using multispectral photoacoustics. Journal of Biophotonics, 9(9), 924–933.
  10. Gabai, H., Steinberg, I., & Eyal, A. (2015). Multiplexing of fiber-optic ultrasound sensors via swept frequency interferometry. Optics Express, 23(15), 18915–18924.
  11. Herzog, A., Steinberg, I., Gaisenberg, E., Nomberg, R., & Ishaaya, A. A. (2015). A route to laser angioplasty in the presence of fluoroscopy contrast media, using a nanosecond-pulsed 355-nm laser. IEEE Journal of Selected Topics in Quantum Electronics, 22(3), 342–347.
  12. Shacham, R., Steinberg, I., Gandjbakhche, A. H., & Gannot, I. (2014). Monitoring LITT thermal penetration depth using real-time analysis of backscattered light. Journal of Biophotonics, 7(6), 381–391.
  13. Steinberg, I., Harbater, O., & Gannot, I. (2014). Robust estimation of cerebral hemodynamics in neonates using multilayered diffusion model for normal and oblique incidences. Journal of Biomedical Optics, 19(7), 071406–071406.
  14. Tsalach, A., Steinberg, I., & Gannot, I. (2013). Tumor localization using magnetic nanoparticle-induced acoustic signals. IEEE Transactions on Biomedical Engineering, 61(8), 2313–2323.
  15. Saltsberger, S., Steinberg, I., & Gannot, I. (2012). Multilayer Mie scattering model for investigation of intracellular structural changes in the nucleolus and cytoplasm. International Journal of Optics, 2012(1), 947607.
  16. Steinberg, I., Kaplan, E., Ben-David, M., & Gannot, I. (2009). The role of skew rays in biomedical sensing. IEEE Journal of Selected Topics in Quantum Electronics, 16(4), 961–966.

Conference Papers & Abstracts

  1. Thornton, M., Cho, J. H., Steinberg, I., Gao, J., & Adamson, C. (2024). NONINVASIVE ASSESSMENT OF STEATOTIC LIVER DISEASE IN INDIVIDUALS WITH CLASS 2 AND CLASS 3 OBESITY. HEPATOLOGY, 80, S631–S632.
  2. Cho, J. H., Thornton, M., Gao, J., Adamson, C., & Steinberg, I. (2023). Thermoacoustic assessment of fatty liver disease-an early clinical feasibility study. Journal of Hepatology, 78, S773–S774.
  3. Park, B., Kim, J., Ha, J., Steinberg, I., Hooper, S., Jeong, C., Park, E., Choi, W., Liang, T., Bae, J. S., & others. (2021). Combinational American Thyroid Association: photoacoustic score as a novel classification method for thyroid cancer nodules in vivo. Photons Plus Ultrasound: Imaging and Sensing 2021, 11642, 116420L.
  4. Kim, J., Park, B., Ha, J., Steinberg, I., Park, E.-Y., Choi, W., Hooper, S., Gambhir, S. S., Lim, D.-J., & Kim, C. (2020). Multispectral photoacoustic assessment of thyroid cancer nodules in vivo. Photons Plus Ultrasound: Imaging and Sensing 2020, 11240, 1124004.
  5. Tummers, W., Swijnenburg, R. J., Miller, S., Teraphongphom, T., Gomez, A., Kothapalli, R., Steinberg, I., Huland, D., Bonsing, B., Vahrmeijer, A., & others. (2019). Tumor-specific intraoperative detection of pancreatic ductal adenocarcinoma using multimodal molecular imaging. HPB, 21, S753.
  6. Hyun, D., Li, Y. L., Steinberg, I., Jakovljevic, M., Klap, T., & Dahl, J. J. (2019). An open source GPU-based beamformer for real-time ultrasound imaging and applications. 2019 IEEE International Ultrasonics Symposium (IUS), 20–23.
  7. Steinberg, I., Huland, D., Tummers, W., Kothapalli, S. R. R., & Gambhir, S. (2018). A model-based acoustic reconstruction algorithm for deep tissue clinical photoacoustic imaging of cancerous tissues labeled with contrast agents (Conference Presentation). Photons Plus Ultrasound: Imaging and Sensing 2018, 10494, 104942G.
  8. Steinberg, I., Tamir, G., & Gannot, I. (2017). Real-time temperature feedback for nanoparticles based tumor thermal treatment (Conference Presentation). Optical Biopsy XV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 10060, 77–77.
  9. Gabai, H., Steinberg, I., & Eyal, A. (2016). All fiber sensor array for ultrasound sensing. Photons Plus Ultrasound: Imaging and Sensing 2016, 9708, 761–766.
  10. Herzog, A., Steinberg, I., & Ishaaya, A. A. (2016). Reduced tissue disruption effects by manipulating pressure transients of UV nanosecond laser pulses. CLEO: Applications and Technology, AW4O–5.
  11. Steinberg, I., Shiloh, L., Gannot, I., & Eyal, A. (2016). The use of dual-wavelength quantitative photoacoustics for evaluation of bone pathologies-a first in human study. CLEO: Applications and Technology, ATh3N–6.
  12. Gabai, H., Steinberg, I., Shiloh, L., & Eyal, A. (2015). All-fiber ultrasound sensor array implemented by swept frequency interferometry. 24th International Conference on Optical Fibre Sensors, 9634, 101–104.
  13. Gabai, H., Steinberg, I., & Eyal, A. (2015). Broadband ultrasonic sensor array via optical frequency domain reflectometry. Photons Plus Ultrasound: Imaging and Sensing 2015, 9323, 222–225.
  14. Steinberg, I., Gannot, I., & Eyal, A. (2015). Investigation of a dual modal method for bone pathologies using quantitative ultrasound and photoacoustics. Photons Plus Ultrasound: Imaging and Sensing 2015, 9323, 111–116.
  15. Steinberg, I., Shiloh, L., Gabai, H., & Eyal, A. (2015). Over 100km long ultra-sensitive dynamic sensing via Gated-OFDR. 24th International Conference on Optical Fibre Sensors, 9634, 121–124.
  16. Steinberg, I., Hershkovich, H. S., Gannot, I., & Eyal, A. (2014). Theoretical and experimental investigation of multispectral photoacoustic osteoporosis detection method. Photons Plus Ultrasound: Imaging and Sensing 2014, 8943, 695–703.
  17. Steinberg, I., Eyal, A., & Gannot, I. (2013). Multispectral photoacoustic method for the early detection and diagnosis of osteoporosis. Photonic Therapeutics and Diagnostics Ix, 8565, 785–793.
  18. Tsalach, A., Steinberg, I., & Gannot, I. (2012). Time difference of arrival based cancer tumor localization using magnetic nano particles induced acoustic signals. MRS Online Proceedings Library (OPL), 1486, imrc12–1486.
  19. Steinberg, I., Kaplan, E., Ben-David, M., & Gannot, I. (2009). Hollow corewaveguides for radiation delivery and sensing: Monte Carlo, ray tracing computer simulation. Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications IX, 7173, 146–152.

Patents

  1. Shmidov, D., MacCarini, P., Steinberg, I., Thornton, M. M., & Davis, C. N. (2025). Radio frequency applicator.
  2. Steinberg, I., Thornton, M. M., Davis, C. N., & Cho, J. H. (2024). Method and system to determine radio frequency antenna electromagnetic field spatial distribution.
  3. Davis, C. N., MacCarini, P., Steinberg, I., & Thornton, M. M. (2023). Thermoacoustic measurement probe.
  4. Sengenberger, J., Davis, C. N., Bull, C., Chen, C., Cho, J. H., Steinberg, I., & Thornton, M. M. (2023). Radio frequency applicator for a thermoacoustic imaging system.
  5. Steinberg, I., & Gambhir, S. S. (2023). Real-time photoacoustic imaging using a precise forward model and fast iterative inverse.
  6. Steinberg, I., & Thornton, M. M. (2023). Thermoacoustic probe.
  7. Eyal, A., Steinberg, I., & Gannot, I. (2017). Detection, diagnosis and monitoring of osteoporosis by a photo-acoustic method.

Theses & Book Chapters

  1. Steinberg, I., Shoval, A., Balberg, M., Sheinfeld, A., Tepper, M., & Gannot, I. (2017). Deep Tissue Imaging: Acoustic and Thermal Wave Propagation and Light Interactions in Tissue. In Deep Imaging in Tissue and Biomedical Materials (pp. 457–487). Jenny Stanford Publishing.
  2. Steinberg, I. (2016). Photoacoustic Methods for Characterization of Bones [PhD thesis]. Tel Aviv University.
  3. Steinberg, I. (2010). Early Detection of Malignant Tumors Using Magnetically Induced Pressure Waves and Specific Nanoparticles [Master's thesis]. Tel Aviv University.
  4. Ben-David, M., Cohen, R., Harbater, O., Steinberg, I., Tepper, M., & Gannot, I. (2006). Ultrashort Laser-Pulse Medical Imaging. In Encyclopedia of Analytical Chemistry: Applications, Theory and Instrumentation. John Wiley & Sons.

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